Abstract
BackgroundPhysical activity (PA) and sedentary behavior (SED) may have independent effects on health and disease. This might be due to PA and SED having distinct effects on lipoprotein metabolism. The aim of this study was to determine associations between lipoprotein subclass particle concentrations (-P) and accelerometer-measured SED and moderate-to-vigorous PA (MVPA) in a sample of healthy adult subjects.MethodsLipoprotein subclass particle concentrations were determined by proton nuclear magnetic resonance spectroscopy, whereas SED and MVPA were measured using Agtigraph GT1M and GT3X+ accelerometers. We obtained valid data in 73 subjects (30 men and 43 women, age 40.5 ± 10.6 years; body mass index 24.0 ± 2.8). Multiple regression analysis was used to determine associations (partial correlations) with lipoproteins.ResultsPositive associations were detected between SED and small VLDL-P, large LDL-P and TG (partial r = 0.24 to 0.25, p < .047). Corresponding associations were non-significant for MVPA (partial r = -0.12 to 0.04, p > .355). On the contrary, MVPA was positively associated with large HDL-P, average HDL size, Apo A1 and HDL-cholesterol (partial r = 0.28 to 0.50, p < .027), whereas SED was not (partial r = -0.06 to 0.07, p > .607).ConclusionThere might be a specific effect of SED versus MVPA on lipoprotein metabolism. However, our results must be interpreted carefully due to possible effect-modification by gender and a low sample size. Thus, our findings should be viewed as preliminary.
Highlights
There is irrefutable evidence of the effectiveness of regular physical activity (PA) in the primary and secondary prevention of a range of chronic diseases as well as premature death [1,2,3]
One male was excluded from the analyses due to very high levels of VLDL-P and TG (z-score > 6) and four subjects did not provide valid data on Physical activity (PA)
The main finding of this study was that there might be a specific effect of sedentary behavior (SED) versus moderate-to-vigorous PA (MVPA) on lipoprotein metabolism
Summary
There is irrefutable evidence of the effectiveness of regular physical activity (PA) in the primary and secondary prevention of a range of chronic diseases as well as premature death [1,2,3]. Sedentary behavior (SED) was conceptualized as the lower end of the PA spectrum, as opposed to moderate- to vigorous PA (MVPA), but is increasingly being viewed as a behavior distinct from PA, defined as any waking behavior characterized by an energy expenditure ≤ 1.5 metabolic equivalents while in a sitting or reclining posture [4] This is supported by studies that have indicated independent associations between SED and mortality, cardiovascular disease, diabetes type 2 and the metabolic syndrome after adjustment for PA [5,6,7].
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