Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study

Suzanne C Dixon-Suen ,Audrey Jung ,A Heather Eliassen ,Christopher A Haiman ,David J Hunter ,Joe Dennis ,Esther M John ,Thérèse Truong ,Michelle Harvie ,Stephen J Chanock ,Saundra S Buys ,Lin Fritschi ,Heli Nevanlinna ,Michael Lush ,Emmanouil Saloustros ,Nick Orr ,Jacques Simard ,Christine L Clarke ,Miriam Dwek ,Christopher Scott ,Thilo Dörk ,Bernardo Bonanni ,Drakoulis Yannoukakos ,Eric Hahnen ,Mikael Eriksson ,Olivia Fletcher ,Douglas F Easton ,Jan Lubiński ,Sara Margolin ,Jennifer Stone ,Mitul Shah ,Hoda Anton‐Culver ,Lukas Schwentner ,Dallas R English ,Heiko Becher ,Nadège Presneau ,W Janni ,Melissa A Troester ,J Lacey ,Rulla M Tamimi ,Melissa H Cessna ,Andrew F Olshan ,Anna Jakubowska ,Montserrat García‐Closas ,Volker Arndt ,Mehdi Manoochehri ,Carl Blomqvist ,William Tapper ,Stig E Bojesen ,Angela Cox ,Don Conroy ,Matthias W Beckmann ,Marı́a Elena Martı́nez ,Rob A.e.m Tollenaar ,Ute Hamann ,Annika Lindblom ,Barbara Wappenschmidt ,Marina Bermisheva ,Kenneth Offit ,Anna Marie Mulligan ,Mary B Daly ,Mark S Goldberg ,Rudolf Kaaks ,Hermann Brenner ,Alpa V Patel ,Zheng Wang ,Usha Menon ,Richard M Martin ,Brigitte Rack ,Christoph Engel ,Anthony J Swerdlow ,Sabine Behrens ,Melissa C Southey ,Abctb Investigators ,Kyriaki Michailidou ,Marike Gabrielson ,Roger L Milne ,Rita K Schmutzler ,Dijana Plaseska‐Karanfilska ,Stella Koutros ,John L Hopper ,Mary Beth Terry ,Renske Keeman ,Terry Boyle ,Paolo Radice ,Dimitriοs Mavroudis ,Manjeet K Bolla ,Annelie Augustinsson ,Kamila Czene ,William G Newman ,Laura E Beane Freeman ,Cari M Kitahara ,Irene L Andrulis ,Dale P Sandler ,Alison M Dunning ,Håkan Olsson ,Henrik Flyger ,Gad Rennert ,Clarice R Weinberg ,Thomas Brüning ,Erika Rees‐Punia ,Fergus J Couch ,Xiao‐Ou Shu ,Maartje J Hooning ,Peter Kraft ,Arto Mannermaa ,Nbcs Collaborators ,Allison W Kurian ,Nicola J Camp ,Niclas Håkansson ,Harald Surowy ,Peter Devilee ,Paul D.p Pharoah ,Atocha Romero ,Sarah J Lewis ,Federico Canzian ,Jenny Chang‐Claude ,Graham G Giles ,Katerina Kubelka-Sabit ,Daniele Campa ,Thomas U Ahearn ,Loı̈c Le Marchand ,Anthony Howell ,Reiner Hoppe ,Manuela Gago-Domínguez ,Marjanka K Schmidt ,Per Hall ,Vessela N Kristensen ,José Á García-Sáenz ,Antoinette Hollestelle ,Alicja Wolk ,Sibylle Loibl ,Peter A Fasching ,Jack A Taylor ,Evans Dm ,Päivi Auvinen ,Lothar Häberle ,Kristan J Aronson ,Ines Nevelsteen ,Melanie Gündert ,Pascal Guénel ,Peter Hillemanns ,Natalia Bogdanova ,Diether Lambrechts ,Rachel A Murphy ,Argyrios Ziogas ,Michael Untch ,Celine M Vachon ,Qin Wang ,Simon S Cross ,Joseph Vijai ,Diana M Eccles ,Christine B Ambrosone ,Julian Peto ,Steven N Hart ,Jose E Castelao ,Brigid M Lynch

doi:10.1136/bjsports-2021-105132

Abstract

ObjectivesPhysical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups...

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