Abstract
BackgroundObesity and physical activity (PA) are predictors of colon (CC) and rectal (RC) cancers. Prolonged sitting is also emerging as a potential predictor for these cancers. Little knowledge exists about the interactive effects of obesity, PA and prolonged sitting on cancer risk. This analysis assessed independent and interactive effects of PA, body mass index (BMI) and sitting time on CC and RC risks.MethodsThis analysis used data from a prospective study of 226,584 participants aged 45 years and over in New South Wales (NSW), Australia, who joined the 45 and Up study between 2006 and 2009. Baseline data were linked with data relating to mortality, cancer registration, hospital admission and Department of Human Services to December 2010. Multivariable Cox regression was used to estimate adjusted hazard ratios (referred to as relative risks, RRs) and 95% confidence intervals (Cis). Statistical significance was defined as p < 0.05.ResultsThere were 846 and 369 ascertained cases of CC and RC. BMI was positively associated with CC risk (p = 0.003, P-trend = 0.0006) but not with RC. CC risk was increased in participants in the highest BMI quartile (≥29.4-≤50 kg/m2) compared to the lowest (15- < 23.6 kg/m2), (RR = 1.32, 95% CI:1.08–1.63). PA was associated with CC risk (p = 0.02) but not with RC. Specifically, CC risk was lower in individuals partaking in any amount of vigorous activity (time/week) compared to participants with no engagement (RR = 0.78, 95% CI:0.65–0.93). Sitting time was not associated with CC or RC. We found no evidence of interactive effects of PA, BMI and prolonged sitting on cancer risk.ConclusionThis evidence suggests that a healthy weight and vigorous activity are essential to reduce CC risk since these factors may be independent of each other.
Highlights
Obesity and physical activity (PA) are predictors of colon (CC) and rectal (RC) cancers
Eligible participants were randomly sampled from the general population of New South Wales (NSW) through the Department of Human Services enrolment database, which provides near complete coverage of the population
For the purpose of this analysis, we used 45 and Up baseline data and record linkage data from the NSW Cancer Registry (NSWCR), Admitted Patient Data Collection (APDC) which are records of patients’ services provided by hospitals in NSW, Medicare Benefits Schedule (MBS) a list of the Medicare services subsidised by the Australian government, Pharmaceutical Benefits Scheme (PBS) and Registry of Birth Deaths Marriages (RBDM)
Summary
Obesity and physical activity (PA) are predictors of colon (CC) and rectal (RC) cancers. Little knowledge exists about the interactive effects of obesity, PA and prolonged sitting on cancer risk. This analysis assessed independent and interactive effects of PA, body mass index (BMI) and sitting time on CC and RC risks. High body fatness, defined as having a body mass index (BMI) greater than 25 kg/m2, has been classified as a confirmed predictor associated with increased risk of colon and rectal cancers [3, 4]. Physical activity (PA) has been established as a predictor associated with a reduced risk of colon cancer (CC), but its association
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