Abstract
BACKGROUND: Physical activity in daily life and exercise capacity have never been assessed in Crohn's disease patients on infliximab-induced remission. We aimed to evaluate the physical activity in daily life, exercise capacity, quality of life and mood disorders in patients with moderate-to-severe Crohn's disease on infliximab-induced remission, and to investigate variables associated with physical activity in daily life in these patients. METHODS: A cross-sectional study was conducted, in which 26 patients with Crohn's disease were selected. Controls were currently asymptomatic individuals with functional dyspepsia. Patients underwent to evaluation of physical activity in daily life by a triaxial accelerometer, exercise capacity (shuttle walk test), handgrip strength, quality of life and mood disorders. RESULTS: The number of steps taken (7446 ± 3081 vs. 7898 ± 2487), the active time (80.6 ± 42 vs. 89.7 ± 24.3 min), the shuttle walk test distance (662.7 ± 252.9 vs. 728.8 ± 346.6 m) and the handgrip (34.3 ± 11.1 kgf vs. 32.9 ± 11.9 kgf) didn't show significant difference between Crohn's disease patients and controls, respectively. The time spending lying down (116.3 ± 107.4 vs. 63.7 ± 55.8 min) and some domains of quality of life were superior in Crohn's disease patients (P<0.05). No correlation was observed between the physical activity in daily life and quality of life or mood disorders in Crohn's disease patients (P>0.05). CONCLUSION(S): In conclusion, moderate-severe CD patients on infliximab-induced clinical remission have the same level of physical activity in daily life and exercise capacity when compared with controls. Some domains of QoL were higher in CD patients. However, because asymptomatic patients with quiescent CD can have as low level of physical activity, it is important that strategies to stimulate physical activity be part of the care for CD patients, so that they can to take up and derive optimal benefit from exercise activities.
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