Abstract
PURPOSE: To compare the physical activity, biochemical and immunological parameters according to the lipodistrophy in HIV-1 infected individuals. METHODS: The sample was constituted by 39 HIV-1 infected men individuals, aged from 25 to 67 year-old (×: 42.19 ± 10.57 years) of the Secondary Immunodeficiency Ambulatory from Hospital das Clínicas (Faculty of Medicine - USP). Physical activity was determined through Baecke questionnaire (Baecke JA, et al. Am J Clin Nutr 1982; 36: 936-42) and separated according to the occupational (OPA), leisure time and locomotion physical activity (LLPA), physical exercises in leisure time (PELT) as well as the total score (TS) that considered all types of physical activity (OPA, LLPA and PELT). Plasma lipoprotein profile measured were total cholesterol (TC), triglycerides (TRI), high density lipoprotein cholesterol (HDL), and low density lipoprotein cholesterol (LDL). T lymphocyte subpopulation (CD4+) counts were analyzed by flow cytometry (Coulter Epics XL, Miami, FL, USA). Viremia was determined by polymerase chain reaction (PCR [Amplicor, Roche]). Volunteers established the presence (YES) or absence (NO) of lipodistrophy according to their self-perception. RESULTS: There were not statistically significant differences in the body composition (body weight: 73.15 ± 10.85 kg × 76.76 ± 16.16 kg; body mass index: 24.67 ±4.00 kg-m2 × 25.78 ± 3.90 kg-m2), physical activity (OPA: 2.46 ± 1.03 × 2.44± 0.93; LLPA: 2.36 ±0.65×2.42 ±0.71; PELT: 1.76 ± 0.68 × 1.65 ± 0.80; TS: 6.59 ± 1.45 × 6.52 ± 1.73), biochemical (CT: 169.85 ± 57.41 mg·dL; × 177.40 ± 37.96 mg·dL; TRI: 224.07 ± 161.38 mg·dL × 213.86 ± 194.55 mg·dL; HDL: 40.64 ± 9.82 mg·dL × 42.20 ± 14.12 mg·dL; LDL: 88.46 ± 46.42 mg·dL × 99.42 ± 38.71 mg·dL) and immunological (CD4: 433.84± 356.26 cells·mm3 × 368.75 ± 271.66 cells·mm3; viremia [log]: 4.84 ± 0.55 × 4.43 ± 0.88) parameters when YES or NO groups were compared with each other, respectivelly. CONCLUSION: Physical activity, biochemical and immunological parameters appear to be not different between HIV-1 infected men individuals which self-perceived the lipodistrophy when compared with those that not self-perceived it. The fact of lipodistrophy has been considered as any change in body composition after HIV infection or pharmacological treatment could produce bias.
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