Physical Activity Behavior and Lipid Profile in HIV+Hispanic Adults

Abstract

Elevated plasma lipids and glucose are metabolic alterations associated with HIV infection and treatment. Studies have shown that structured aerobic and resistance exercise training help control these metabolic disturbances and reduce cardiovascular disease risk factors in this population. However, the metabolic benefits of an unstructured physical activity lifestyle in HIV+adults are not clear. Purpose: To determine if HIV+adults who follow the physical activity recommendations have a better lipid and glucose profile compared to inactive HIV+adults. Methods: Thirty eight HIV+adults (16 females, 22 males; age= 46.8±9.8 y) taking antiretroviral medications volunteered to wear an accelerometer for seven consecutive days and provide a copy of their most recent lipid and glucose laboratory test results. Participants were classified as active if engaged in =150 min/wk of moderate to vigorous physical activity (MVPA). Waist circumference, height and weight were measured; and questions were asked regarding smoking behavior and previous day diet. Results: Means and standard deviations of glucose, triglyceride and cholesterol were: 105.1±48.0 mg/dl, 209.7±110.3 mg/dl, and 187.6±53.9 mg/dl, respectively. Elevated levels of glucose (>125 mg/dl), triglycerides (>200 mg/dl) and cholesterol (>200 mg/dl) were observed in 3 (8%), 17 (45%), and 10 (26%) participants, respectively. Blood lipid and glucose levels were not significantly different between those classified as physically active (29%) and those classified as inactive (71%). There were no significant associations between blood lipids and glucose levels and BMI, waist circumference, weight, or smoking behavior. However, participants with elevated triglycerides had a significantly higher energy intake vs. energy expenditure (752.9±511.3 Kcal/d) compared to those with normal triglyceride levels (260.8±243.3 Kcal/d). Conclusion: The minimal recommended level of MVPA/wk was not protective against lipid disorders in the group of HIV+Hispanic adult participants, particularly when physical activity is unstructured and no dietary intervention is provided. This study was supported by NIH/NCRR 5 R25 RR17589 and NIH/NCI P20 CA096257.