Abstract
BackgroundRenal cell carcinoma (RCC) has a higher incidence in blacks than in whites. Physical activity may influence the risk of renal cell cancer, but the evidence is inconsistent. No previous study has investigated this relationship in the black population.MethodsWe examined the association between self-reported physical activity at different ages and risk of RCC in a population based case-control study of 1217 cases (361 black, 856 white) and 1235 controls (523 black, 712 white) frequency-matched on age, race, and gender. Multivariate-adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression.ResultsAmong whites, increased risks of RCC were observed among participants reporting low levels of transportation-related activity in their 20’s (OR <1 hr/wk vs >7 hr/wk (95% CI): 1.42 (1.10, 1.83)) and leisure time activity in their 50’s (OR <1 hr/wk vs >7 hr/wk (95% CI): 1.49 (1.00, 2.20)). We found no association between physical activity and RCC risk among blacks.ConclusionOur results suggest that physical activity may be inversely associated with RCC risk in whites, but there was no evidence of such an association in blacks. As this is the first study evaluating the effect of physical activity on RCC risk among blacks, further investigations are needed to clarify the relationship in this population.Electronic supplementary materialThe online version of this article (doi:10.1186/1471-2407-14-707) contains supplementary material, which is available to authorized users.
Highlights
Renal cell carcinoma (RCC) has a higher incidence in blacks than in whites
In order to recruit a sufficient number of African Americans, we devised a sampling strategy aimed at enrolling all eligible black cases, but only a subsample of white cases
In both blacks and whites, when compared to controls, cases were more likely to have
Summary
Renal cell carcinoma (RCC) has a higher incidence in blacks than in whites. Physical activity may influence the risk of renal cell cancer, but the evidence is inconsistent. The incidence of renal cell carcinoma (RCC), the major subtype that accounts for ~90% of all kidney cancers, has been increasing rapidly in U.S over the past three decades [2]. Some studies found an inverse relationship between some aspect of physical activity and RCC risk [5,6,7,8,9,10,11,12], yet others found null associations [13,14,15,16,17,18,19,20,21,22].
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