Abstract
Objective. The purpose of the study was to assess total antioxidant capacity (TAC) of blood serum in relation with habitual leisure time physical activity (LTPA) and aerobic capacity in a group of 90 men with coronary heart disease (CHD) aged 34.8–77.0 years and in 90 age-matched peers without CHD. Methods. Two spectrophotometric methods were applied to assess TAC: Ferric Reducing Ability of Serum (TAC-FRAS) and 2.2-diphenyl-1-picryl-hydrazyl (TAC-DPPH) tests. Aerobic capacity was expressed as physical working capacity at 85% of the maximal heart rate (PWC85%HRmax). Results. CHD patients had higher values of TACFRAS (1.37 ± 0.28 versus 1.27 ± 0.23 mmol FeCl2·L−1; P < 0.05) but there were no group differences for TAC-DPPH and for uric acid (UA). Negative correlation was found between LTPA (also when calculated per kg of body mass) and TAC-DPPH in CHD patients. In CHD patients, TAC-FRAS and UA were lower in subjects with higher aerobic capacity expressed as PWC85%HRmax/kg. Those associations were not found in healthy men. Conclusions. We conclude that TAC of blood serum is moderately adversely related to LTPA and aerobic capacity in patients with CHD. UA, as the main determinant of serum TAC, may be partially responsible for those associations.
Highlights
Numerous studies focus on the role of antioxidant potential and reactive oxygen species in the aging process as well as in the pathogenesis of common civilization diseases, such as cardiovascular diseases [1, 2]
Men with coronary heart disease (CHD) were characterized by higher values of body mass, body mass index (BMI), waist circumference, waist-to-hip ratio (WHR), and percentage of body fat in comparison with men without CHD
Among the patients with CHD, significantly more subjects had smoked in the past than in the group of men without CHD
Summary
Numerous studies focus on the role of antioxidant potential and reactive oxygen species in the aging process as well as in the pathogenesis of common civilization diseases, such as cardiovascular diseases [1, 2]. Reactive oxygen species are essential to the normal cell functioning, but coexistent antioxidant defenses are necessary to avoid the damaging effects of excessive free radicals production. The results of available data are full of discrepancies and the present state of knowledge on such dependence is still not complete [6, 7] It is not evidenced whether the incidence of coronary heart disease (CHD) is related to a decrease in antioxidant potential. Antioxidant potential assessment should include characteristics of PA applied together with the characteristics of the subjects like age, health status, and other potentially modifying factors. These results seem to be crucial for planning cardiac rehabilitation in CHD patients
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