Abstract

Asthma is the commonest respiratory disease and one of unceasingly increasing prevalence and burden. As such, asthma has attracted a major share or scientific interest and clinical attention. With the various clinical and pathophysiological aspects of asthma having been extensively investigated, the important association between asthma and physical activity remains underappreciated and insufficiently explored. Asthma impacts adversely on physical activity. Likewise, poor physical activity may lead to worse asthma outcomes. This concise clinical review presents the current recommendations for physical activity, discusses the available evidence on physical activity in asthma, and examines the causes of low physical activity in adult asthmatic patients. It also reviews the effect of daily physical activity and exercise training on the pathology and clinical outcomes of asthma. Finally, it summarizes the evidence on interventions targeting physical activity in asthma.

Highlights

  • Asthma is a heterogeneous chronic inflammatory disease of the airways that is defined by the history of respiratory symptoms such as wheeze, shortness of breath, chest tightness and cough that vary over time and in intensity, together with variable expiratory airflow limitation [1]

  • Physical activity in daily life (PADL) in severe asthmatics was associated with impulse oscillometric airway resistance and small airway dysfunction, albeit not with gold-standard airflow limitation measured by forced expiratory volume in 1 s (FEV1) and peak expiratory flow rate (PEFR) [36]

  • We have previously reported findings on limited daily moving time daily step count (7142 ± 2952), and weekly metabolic equivalents-minutes (MET-min) (509 ± 189) in 12 patients with severe asthma [39]; movement intensity measured in acceleration units was found to be 1.81 ± 0.18 m/s2, which compares with that of older patients with moderate-to-severe chronic obstructive pulmonary disease (COPD) [40]

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Summary

Introduction

Asthma is a heterogeneous chronic inflammatory disease of the airways that is defined by the history of respiratory symptoms such as wheeze, shortness of breath, chest tightness and cough that vary over time and in intensity, together with variable expiratory airflow limitation [1]. Physical activity in asthma warrants attention and focus This concise clinical review presents the current recommendations for physical activity, discusses the available evidence on physical activity in asthma, and examines the causes of low physical activity in adult asthmatic patients. It reviews the effect of daily physical activity and exercise training on the pathology and clinical outcomes of asthma. It summarizes the evidence on interventions targeting physical activity in asthma

Physical Activity Nomenclature and Recommendations
Physical Activity in Asthma
Causes for Low Physical Activity in Asthma
The Effect of Physical Activity in Asthma
The Effect of Exercise Training in Asthma
Additional Mechanisms of Benefit
Interventions Targeting Physical Activity in Asthma
Pharmacological Interventions
Behavioral Interventions
Findings
Conclusions
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