Phylogeny of Wilms tumor?

Adrian Charles

doi:10.1016/j.ebiom.2016.06.044

Abstract

Phylogeny of Wilms tumor?

Highlights

The paper by Cresswell et al (2016) addresses important issues in understanding the heterogeneous pathogenetic pathways in Wilms tumors and practical questions of how sensitive and specific is a tumor biopsy for identifying important genetic changes
If therapy is going to be based on the tumor genetics, we need a clear understanding of the pathogenetic pathways and the likelihood of identifying key prognostic/ diagnostic information in a tumor biopsy
The question for pediatric tumors, is how do steps occur at such a young age and are there fewer steps? One point to note is that small round blue cell tumors of childhood tend to be rapidly proliferative and time should be measured by cell cycles, rather than months and years

Summary

Introduction

The paper by Cresswell et al (2016) addresses important issues in understanding the heterogeneous pathogenetic pathways in Wilms tumors and practical questions of how sensitive and specific is a tumor biopsy for identifying important genetic changes. If therapy is going to be based on the tumor genetics, we need a clear understanding of the pathogenetic pathways and the likelihood of identifying key prognostic/ diagnostic information in a tumor biopsy. Wilms tumors though appear genetically heterogeneous, with some tumors showing few changes and others showing more changes as the current paper demonstrates (Cresswell et al, 2016).

Results

Conclusion