Abstract
Phylogeny of Wilms tumor?
Highlights
The paper by Cresswell et al (2016) addresses important issues in understanding the heterogeneous pathogenetic pathways in Wilms tumors and practical questions of how sensitive and specific is a tumor biopsy for identifying important genetic changes
If therapy is going to be based on the tumor genetics, we need a clear understanding of the pathogenetic pathways and the likelihood of identifying key prognostic/ diagnostic information in a tumor biopsy
The question for pediatric tumors, is how do steps occur at such a young age and are there fewer steps? One point to note is that small round blue cell tumors of childhood tend to be rapidly proliferative and time should be measured by cell cycles, rather than months and years
Summary
The paper by Cresswell et al (2016) addresses important issues in understanding the heterogeneous pathogenetic pathways in Wilms tumors and practical questions of how sensitive and specific is a tumor biopsy for identifying important genetic changes. If therapy is going to be based on the tumor genetics, we need a clear understanding of the pathogenetic pathways and the likelihood of identifying key prognostic/ diagnostic information in a tumor biopsy. Wilms tumors though appear genetically heterogeneous, with some tumors showing few changes and others showing more changes as the current paper demonstrates (Cresswell et al, 2016).
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
