Abstract
Abstract. The Swine Leukocyte Antigen (SLA) class I consists of SLA-1, SLA-2, and SLA-3 genes (CHARON et al., 2000) that are expressed on the surface of most nucleated cells. Pig organs mainly from miniature pigs have been used in studies on xenotransplantation (SMITH et al., 2005). It is important to understand genetic variations of the SLA-1 gene considering the SLA-mediated immune responses. Collecting information on single nucleotide polymorphisms (SNPs) and alleles of SLA-1 and their phylogenic relationships is important regarding future uses of the Korean Jeju Pig (KJP) in xenotransplantation.
Highlights
Phylogenic analysis of the Swine Leukocyte Antigen (SLA)-1 gene variants observed from Korean Jeju pig (Brief Report)
The Swine Leukocyte Antigen (SLA) class I consists of SLA-1, SLA-2, and SLA-3 genes (CHARON et al, 2000) that are expressed on the surface of most nucleated cells
Procedure Primer sequences: Primers were designed from the swine coding sequence (GenBank accession No.: AY247766 and AF464016) of porcine SLA-1 consisting of 8 exons in 1,087 bp length. forward primer: 5 ́-GGGCGTCGACCAGACTCCGAGGCTGAGG-3 ́ reverse primer: 5 ́-GAAGGTTCTCAATCCTTCCATTT-3 ́
Summary
The Swine Leukocyte Antigen (SLA) class I consists of SLA-1, SLA-2, and SLA-3 genes (CHARON et al, 2000) that are expressed on the surface of most nucleated cells. Phylogenic analysis of the SLA-1 gene variants observed from Korean Jeju pig (Brief Report) (Phylogenetische Analyse von SLA-1 Genvarianten beim koreanischen Jeju Schwein)
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