Abstract
Identification of gene clusters in Streptomyces holds promise for the discovery of regulatory pathways linked to bioactive metabolites. We isolated a broad-spectrum antibacterial potential Streptomyces sp BDUSMP 02 from mangrove sediment. We further found a distinct of phylogeny pattern for NRPS A-domain in the Streptomyces sp BDUSMP 02. The result suggests that Streptomyces sp BDUSMP 02 has the potential to produce a new type of antibacterial compounds belonging to NRPS type.
Highlights
In the last five decades, natural compounds produced by actinobacteria have been enormously utilized to develop most of the common antibiotics commercialized by pharmaceutical industries [1]
Streptomyces sp isolated from mangrove ecosystem have been able to grow in freshwater, brackish water and seawater which suggest that they are adapted to various environmental conditions due to the water current [7]
The biological functions of non-ribosomal peptide synthetase (NRPS) via synthesized compounds associated with the chemical nature of peptide, which is correlated with the gene sequence [11]
Summary
In the last five decades, natural compounds produced by actinobacteria have been enormously utilized to develop most of the common antibiotics commercialized by pharmaceutical industries [1]. Isolation of actinomycetes from unexplored marine environment has been attracted particular attention due to their structural diversity and distinct bioactivities of secondary metabolites produced by them [2]. Bissett et al (2007) reported that mangrove sediments are known to contain high organic content, which favour the rapid development of species diversity corresponding to environmental variation [5]. It is evident that gene clusters in Streptomyces likely to encode natural product biosynthetic pathways in sequenced microbial genomes [9]. Komaki and Harayama (2006) reported that DNA sequence based on these genes could be used to predict the chemical nature of compounds [14]. The biological functions of NRPS via synthesized compounds associated with the chemical nature of peptide, which is correlated with the gene sequence [11]. It is crucial to study the phylogenic insight of NRPS in the potential actinomycete would provide new opportunities for drug discovery
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