Abstract
To explore the epidemic history of HIV-1 CRF01_AE in China, 408 fragments of gag gene sequences of CRF01_AE sampled in 2002–2010 were determined from different geographical regions and risk populations in China. Phylogenetic analysis indicates that the CRF01_AE sequences can be grouped into four clusters, suggesting that at least four genetically independent CRF01_AE descendants are circulating in China, of which two were closely related to the isolates from Thailand and Vietnam. Cluster 1 has the most extensive distribution in China. In North China, cluster 1 and cluster 4 were mainly transmitted through homosexuality.The real substance of the recent HIV-1 epidemic in men who have sex with men(MSM) of North China is a rapid spread of CRF01_AE, or rather two distinctive natives CRF01_AE.The time of the most recent common ancestor (tMRCA) of four CRF01_AE clusters ranged from the years 1990.9 to 2003.8 in different regions of China. This is the first phylogenetic and temporal dynamics study of HIV-1 CRF01_AE in China.
Highlights
China is the world’s most populous country, where the human immunodeficiency virus type 1 (HIV-1) epidemic is still increasing
Sexual transmission continues to be the primary mode of transmission, and homosexual transmission is increasing rapidly
Of the 780,000 people estimated to be living with HIV in 2011, the percentage of infected cases through sexual transmission was 63.9% in which 46.5% were infected through heterosexual transmission and 17.4% through homosexual transmission
Summary
China is the world’s most populous country, where the human immunodeficiency virus type 1 (HIV-1) epidemic is still increasing. At the end of 2011, the estimated number of people living with HIV in China was 780,000. Prevalence among the population as a whole was 0.058%; Of the total number of people living with HIV, 154,000 were cases of Acquired Immune Deficiency Syndrome(AIDS). It is estimated that there were 48,000 new cases of HIV in 2011, and that the prevalence among the population as a whole was 0.057%. HIV/ AIDS is the leading cause of death from infectious diseases in China, accounting for an estimated 28,000 deaths in 2011. Of the 780,000 people estimated to be living with HIV in 2011, the percentage of infected cases through sexual transmission was 63.9% in which 46.5% were infected through heterosexual transmission and 17.4% through homosexual transmission. Among the 48,000 new cases estimated for 2011, heterosexual transmission accounted for 52.2%, homosexual transmission 29.4%, and IDU accounted for 18.0% of cases [1]
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