Abstract
Objective: To clarify the evolutionary characteristics and transmission mode of DENV-1 genotype I dengue virus in the Asia-Pacific region. Methods: 200 DENV-1 genotype I dengue viruses in the Asia-Pacific region from 2010 to 2014 and 2015 to 2019 were used for phylogenetic analysis and bayesian phylogeographic analysis using a series of molecular biology software. Results: DENV-1 genotype I dengue virus spread frequently between coastal cities in China and Southeast Asian countries. The evolution rate of DENV-1 genotype I dengue virus during 2010-2014 was 5.73×104 (/site/year,95%CI) , and the time to the most recent common ancestor was 1970-09-14.And the evolution rate of virus during 2015-2019 was 5.25×104 (/site/year,95%CI) , and the time to the most recent common ancestor was 1978-10-30.The virus spatial diffusion pathways shows the phenomenon that the dengue virus of this genotype is widespread in the Asia-Pacific region, the spread of the dengue virus between the coastal provinces and some inland provinces of China, and Southeast Asian countries. The study results indicated that the monitoring and preventive measures should be strengthened to avoid the threat of personal safety caused by large-scale spread of DENV-1 in China.
Highlights
Dengue virus (DENV) is an arbovirus of the Flaviviridae of the Flaviviridae family
This study aimed to explore the evolution and spread of DENV-1 genotype I virus in Southeast Asia and surrounding areas, using phylogenetic analysis methods to draw migration maps (Figure 2, Figure 3)
The disease caused by the dengue virus is widespread in Africa, America, Southeast Asia, and the Western Pacific including China On a global scale
Summary
Dengue virus (DENV) is an arbovirus of the Flaviviridae of the Flaviviridae family. Each serotype is further divided into 4 or 5 genotypes according to its genetic diversity The infection of DENV is spreading rapidly around the world, and more than half of the world’s population is at risk of infection. It has become one of the most harmful media diseases in the world [2]. About 1.8 billion (over 70%) of high-risk populations of dengue fever live in Southeast Asia and the Western Pacific, accounting for nearly 75% of the current global dengue fever [4,5]
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