Phylogenetic analysis of human bocavirus (HBoV) detected from children with acute respiratory infection in Japan

Abstract

Human bocavirus (HBoV) belongs to family Parvoviridae and causes acute respiratory infection (ARI) in humans. 1 Allander T. Human bocavirus. J Clin Virol. 2008; 41: 29-33 Abstract Full Text Full Text PDF PubMed Scopus (144) Google Scholar HBoV is an emerging virus discovered by Allander et al. in 2005 from a Swedish patient with ARI. 2 Allander T. Tammi M.T. Eriksson M. Bjerkner A. Tiveljung-Lindell A. Andersson B. Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc Natl Acad Sci U S A. 2005; 102: 12891-12896 Crossref PubMed Scopus (1267) Google Scholar Although the clinical course of HBoV infection in most patients is good, it is suggested that HBoV is associated with lower respiratory infection including bronchiolitis and pneumoniae 3 Schildgen O. Müller A. Allander T. Mackay I.M. Völz S. Kupfer B. et al. Human bocavirus: passenger or pathogen in acute respiratory tract infections?. Clin Microbiol Rev. 2008; 21: 291-304 Crossref PubMed Scopus (247) Google Scholar , 4 Chieochansin T. Samransamruajkit R. Chutinimitkul S. Payungporn S. Hiranras T. Theamboonlers A. et al. Human bocavirus (HBoV) in Thailand: clinical manifestations in a hospitalized pediatric patient and molecular virus characterization. J Infect. 2008; 56: 137-142 Abstract Full Text Full Text PDF PubMed Scopus (36) Google Scholar , 5 Calvo C. García-García M.L. Blanco C. Santos M.J. Pozo F. Pérez-Breña P. et al. Human bocavirus infection in a neonatal intensive care unit. J Infect. 2008; 57: 269-271 Abstract Full Text Full Text PDF PubMed Scopus (22) Google Scholar ; however, its epidemiology remains poorly understood at present. 3 Schildgen O. Müller A. Allander T. Mackay I.M. Völz S. Kupfer B. et al. Human bocavirus: passenger or pathogen in acute respiratory tract infections?. Clin Microbiol Rev. 2008; 21: 291-304 Crossref PubMed Scopus (247) Google Scholar In this study, in an attempt to clarify the epidemiology, we performed phylogenetic analysis of HBoV detected from Japanese children with ARI in recent years.