Abstract
BackgroundCystosarcoma phylloides (CP) is an extremely rare form of breast cancer with an unpredictable clinical course. The histological characteristics of this neoplasm have not proved to offer much in the estimation of prognosis of these patients.Patients and methodsIn our clinics, in a time period of 38 years, 22 patients with cystosarcoma phylloides were treated. There were 5 cases of malignancy, 15 cases with benign tumors, and two cases histologically characterized as borderline neoplasia. Metastases were manifested in one patient. All patients were on a 5-year follow-up, except in five cases, one operated three years ago and four operated within the last two years.Results16 of 22 patients did not present any signs of local recurrence or metastases. There were three patients that manifested local recurrence and underwent supplementary ongectomy or mastectomy and are free of recurrence ever since. One patient with metastatic CP died.ConclusionIndependently of its histopathological behavior, CP is a tumor difficult to be treated. Meticulous follow-up is mandatory in order to manage possible recurrence of the neoplasm.
Highlights
Cystosarcoma phylloides (CP) is an extremely rare form of breast cancer with an unpredictable clinical course
Cysteosarcoma phylloides (CP) constitutes a rare form of breast neoplasia, which represents less than 1% of total breast neoplasias and only 2,3% of all fibro-epithelial breast tumors [1,2,3,4]
Histological examination of the resected breast segment revealed a benign lesion in 15 cases, a malignant tumor in 4 cases, while in the remaining two cases the neoplasm was characterized as borderline
Summary
Cystosarcoma phylloides (CP) is an extremely rare form of breast cancer with an unpredictable clinical course. Cysteosarcoma phylloides (CP) constitutes a rare form of breast neoplasia, which represents less than 1% of total breast neoplasias and only 2,3% of all fibro-epithelial breast tumors [1,2,3,4] It was first described by Muller in 1838, who introduced the term "cystosarcoma phylloides" because of the extensions of the tumor mimicking the shape of leaves, intruding within the cystic cavities of the tumor [5]. This neoplasm is manifested in women of all ages, including adolescent and the elderly, with the majority ranging between 35 and 54 years [6,7,8,9,10]. The remaining three were previously treated in other institutions and were referred to our hospital for further treatment
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