Abstract
O-30C7-3 Background/Aims: Previous studies on phthalate exposure to children have shown that phthalate concentration was adversely associated verbal IQ and symptoms of ADHD in school-aged children. They have investigated a relatively limited range of variables. In this study, we extended the investigation to parents-rated behavioral problem by phthalate exposure using path analysis. Methods: A total of 1089 school aged children(mean age = 9.05 ± 0.7) has been enrolled in this study from 2008 to 2009 in 5 cities. Children's urine was collected and analyzed for phthalate metabolites. Mono-2-ethylheyl phthalate (MEHP) and mono-2-ethyl-5-oxohexylphthalate (MEOP) and mono-n-butyl phthalate (MNBP) were measured in urine samples. Children were assessed for the intellectual functioning and inattention/hyperactivity-impulsivity symptoms using the continuous performance test (CPT). Children's parent evaluated their child's behaviors using Children's Behavioral Check List (CBCL). Path analysis was used to determine the relationship between variables. Results: In multivariate adjusted models, increased log concentrations of MNHP and MNOP were associated with poorer scores on the verbal IQ (beta [SE] = −0.568 [0.253] P = 0.025), the score of Commission error on CPT (beta [SE] = 2.595 [1.01] P = 0.01), and higher scores of social problems and attention problems on CBCL were associated with increased MNHP and MNOP concentrations. (beta [SE] = 0.807 [0.243] P = 0.001, beta [SE] = 0.403 [0.204] P = 0.048). Path analysis models revealed differences in the variables predicting behavioral problems of Children. Increased phthalate concentrations had strong direct negative effects on Verbal IQ and Commission error on CPT. Specifically, increased phthalate concentrations measures mediated the role of verbal IQ, commission error on CPT in predicting behavioral problems on CBCL. Phthalate had an indirect effect on Behavioral Problems (Social problems, Attention problems). This result provided an excellent fit to the data. (NFI = 0.945, CFI = 0.950, RMSEA = 0.089) Conclusion: This study suggests that phthalate exposure may be associated social and attention problems mediated by poorer verbal IQ and higher scores of commission error on test.
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