Abstract
Condensation of phthalaldehydic acid with nitromethane in alkaline state affords o-(2-nitrovinyl) benzoic acid in a good yield, Its reduction with phosphorus and hydriodic acid to form o-(2-aminovinyl) benzoic acid hydriodide and its treatment with alkali and hydrochloric acid gave isocarbostyril in 70% yield. After reduction of o-(2-nitrovinyl) benzoic acid with stannous chloride and hydrochloric acid, treatment of the reduction product with hydrochloric acid also afforded isocarbostyril.
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