Abstract
To assess the factors associated with high allopurinol adherence. Allopurinol prescription was defined as at least 30 days of a filled allopurinol prescription. Patients were censored when they switched from allopurinol to one of the other ULT. Index allopurinol prescription was defined as not exposed to allopurinol for 121 days (which contains 30 days grace period for refilling and 91 days for washout In multivariable-adjusted that adjusted for all factors except medication and disease severity factors (model 5), we found that the following factors were significantly associated with higher odds of allopurinol MPR ≥80%: older age, Caucasian race, being currently married; gout care from primary care provider specialty, smaller facility bed size, community-based outpatient clinic and Midwest location; means test, service connection ≥50% and longer distance to the nearest VA. Higher BMI had a non-significant trend towards higher odds of allopurinol MPR ≥80%. In this study, we identified several novel factors associated with allopurinol adherence. This new knowledge can be used to improve the likelihood of success of lowering serum urate with allopurinol pharmacotherapy by targeting modifiable risk factors identified in our study.
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