PH-responsive cellulose-based dual drug-loaded hydrogel for wound dressing

Abstract

A pH-responsive hydrogel having a drug combined effect was prepared for wound dressing by using dialdehyde carboxymethyl cellulose, tobramycin, β-cyclodextrin derivative and borneol. As a crosslinking agent, the aminoglycoside antibiotic drug tobramycin crosslinks dialdehyde carboxymethylcellulose to form a hydrogel through imine bonds. The positively charged cyclodextrin derivatives containing the auxiliary drug borneol are dispersed inside the hydrogel by electrostatic attraction with carboxyl groups. Imine bonds can break in response to the weakly acidic environment at the wound, thereby drugs and moisture inside the hydrogel are released to promote wound healing. Animal models and histological analysis indicate that the hydrogel achieves a satisfactory therapeutic effect in promoting wound healing. This hydrogel system is also applicable to other drugs containing multiple amino groups, such as neomycin, amikacin, streptomycin, etc., and has potential applications in the field of medicine.