Abstract
Na+/H+ exchangers and intracellular pH (pHi) regulation assumed a central position in the study of fertilization following the discovery that egg activation in the sea urchin is triggered in part by a substantial pHj increase immediately after fertilization, and that this increase is mediated by the activation of Na+/H+ exchange (1). In mammals, the regulation of pHi has been extensively studied in early embryos, with more recent attention given to the role of pHi-regulatory mechanisms during fertilization and meiosis in the oocyte. This review will focus principally on pHi-regulatory mechanisms in mammalian oocytes and preimplantation embryos during meiosis, fertilization, and embryo development.
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