Phragmalin-type Limonoids from Heynea trijuga

Abstract

Nine new phragmalin-type limonoids, heytrijumalins A-I (1-9), together with the known 15-acetyltrichagmalin E (10) were isolated from the branches and leaves of Heynea trijuga. The structures of these new compounds were elucidated on the basis of extensive spectroscopic analysis. Compounds 6 and 10 showed insecticidal activity at 100 ppm, with corrected mortalities of 82.94 % and 96.02 %, respectively. Compounds 2 and 10 showed weak cytotoxicity against HL-60 and A-549 human tumor cell lines, with IC₅₀ values ranging from 14.55 to 25.27 µM.