Abstract
In Ukraine the pharmacovigilance system for adverse reactions is working. In 2008 was received 7,115, 2009 – 8291, 2010 – 8673, 2012- 11674 card-reports of adverse reactions (AR) drugs. MoH conducted a detailed analysis of these reports found that 13% of them experienced serious adverse events, and 0.7% of the cards with the unexpected AR. We analyzed the side effects depending on the ATC-group drugs. We found that antimicrobial agents for systemic use the largest number of reports received on AR (75.4%), which in most cases manifested anaphylactic AR. Further analysis showed that AR often were drugs (by INN): ceftriaxone (12.6%), amoxicillin in combination with clavulanic acid (8.0%), levofloxacin (6.3%). Among the cardiovascular drugs, reports AR often came on enalapril (10.0%), pentoxifylline (9.7%) and amlodipine (8.1%).Among the drugs affecting the nervous system, haloperidol (7.4%), metamizol sodium (7.4%) and paracetamol (7.0%). The analysis showed that the ratio of serious not serious AR under anti-neoplastic drugs and antiretroviral drugs is 1:2, anti-TB drugs - 1:3, and those affecting the cardiovascular system, gastrointestinal tract, respiratory system - under 1:9, 1 : 6, 1:6. Thus, the frequency of serious AR is much higher in the application of anti-neoplastic, anti-HIV and anti-TB drugs.The greatest risk AR was for children aged 28 days - 11 years, especially boys, and adults, especially women aged 46-60 years. Results of the analysis of AR indicate that needed pharmaceutical care when dispensing antiretrovirals, anti-tuberculosis, anti-neoplastic drugs that meet the requirements of Good pharmacy practice in Ukraine. Implementation of training courses and programs for pharmacists on the subject of safe use of drugs to treat infectious diseases, tuberculosis and HIV / AIDS is essential. As well as acquiring skills pharmaceutical care and prevent AR in dispensing drugs to children and women 45-60 years.
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