Abstract
Erythema was produced in the skin of hairless mutant mice by a single exposure to a solar simulator ( λ > 290 nm). Topical pretreatment of the mice with either anthracene or 8-methoxypsoralen (8-MOP) intensified the reaction more than did pretreatment with the vehicle (methanol) alone. Skin tumours were produced in hairless mice during several months of daily topical treatment followed by exposure to the solar stimulator. Compared with the vehicle-treated group, the 8-MOP group developed more tumours and had a shorter tumour latent period. Tumour production in the anthracene group was not significantly different from that of the vehicle-treated group. Under the conditions of this test, enhanced photocarcinogenesis is not a necessary consequence of prolonged contact with the phototoxic agent anthracene.
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