Abstract
The liposomal encapsulation of antibiotics offers advantages from the aspect of bioavailabilty and therapeutical efficacy. As among antibiotics many possess phototoxic properties, and during preparation (e.g. sterilization), storage or in case of topical application ultraviolet light exposure can be present, photodegradation of liposomal antibiotics should be taken into consideration. Thus, the examination of lipid-phototoxic drug interactions in the presence of ultraviolet light is of great importance. In some cases liposomal encapsulation can alter the ways and rates of photodegradation, leading to the formation of more or less (photo)toxic compounds. Through the examples of selected phototoxic antibiotics (nalidixic acid and lomefloxacin) we highlight the role of liposomal composition in altering the photodegradation process of drug molecules,- leading to possible changes either in the ways or in the rates of their photodegradation.
Highlights
The electrons of photoactive compounds being localized in the skin can be excited by appropriate wavelengths of electromagnetic radiation penetrating through the skin and being absorbed in the phototoxic chemicals
E.g. fluoroquinolone (FQ) antibiotics may induce DNA breaks leading to cell death
As phototoxic reactions develop in most individuals if they are exposed to sufficient amounts of light and drug, the limitation of drug and/or light exposure can minimalize the risk of phototoxic reactions
Summary
Phototoxic Antibiotics and Aspects of their Liposomal Encapsulation: A Mini-Review. 7. Phototoxic Antibiotics and Aspects of their Liposomal Encapsulation: A Mini-Review. 7. H-1092 Budapest, Hungary 2Department of Chemistry, Sam Houston State University, Huntsville, TX, 77341, USA. Received date: September 16, 2018; Accepted date: September 21, 2018; Published date: September 27, 2018
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