Abstract
In this paper, a simple method to prepare hydrophilic reduced graphene oxide (rGO) was proposed via reducing GO by amino-terminated hyperbranched polymer (NHBP), the as-prepared NrGO could present excellent dispersibility, near infrared (NIR) light absorbance, photothermal conversion ability and stability. Then, the doxorubicin hydrochloride (DOX) was conjugated with NrGO to prepare the drug-loading system, and a pH/photothermal dual-responsive drug delivery behavior was characterized. At acidic environment or under NIR laser irradiation, the drug release rate could be improved, which is beneficial to control release anti-tumor drug in tumor tissues. What is more, the in vitro cell experiments revealed that NrGO was well biocompatible, and in the tumor inhibition part, comparing to the control group without any treatment, DOX@NrGO gained efficient chemo-photothermal synergetic therapy, the inhibition rate of which was much higher than single chemotherapy of released DOX. Therefore, the as-prepared DOX@NrGO obtained great potential application in tumor therapy and an excellent candidate in other biomed applications.
Highlights
Photothermal therapy (PTT) under near infrared (NIR) irradiation has attracted raising attention for tumor inhibition, due to the little side effect and minimal invasive properties [1]
Physical and Chemical Characterization After reacting with Amino-terminated HBP (NHBP), the Graphene oxide (GO) solution turned to black from brown, indicating that GO was successfully reduced to reduced graphene oxide (rGO) and dispersible in water
According to the molecular structure of amino-terminated NHBP, the reductive amino group reacted with GO and new FT-IR peak was generated at 1633 cm−1, which supposed to be C-N from amido bond
Summary
Photothermal therapy (PTT) under near infrared (NIR) irradiation has attracted raising attention for tumor inhibition, due to the little side effect and minimal invasive properties [1]. The collected DOX@NrGO was divided into three groups for different treatment to investigate the drug delivery behavior: (1) dispersing in PBS solution with pH = 7.4, marked as control group; (2) dispersing in PBS solution with pH = 4.0, marked as acid group; (3) dispersing in PBS solution with pH = 7.4 and irradiated with NIR laser, marked as NIR group.
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