Abstract
In this work, we prepared hollow gold nanospheres (HAuNS) with rough surfaces and strong light absorption in the NIR region. Based on as-made HAuNS materials, photothermal sterilization patches using filter paper was prepared. When 808 nm and 4 W/cm2 laser light was irradiated on the patch containing 50 ppm of HAuNS, the temperature of patch surface increased to 63 °C. The photothermal conversion efficiency of the patch was found to be 38.8% and is enhanced by the overlap between the heat emission of nearby particles in the patch. The prepared patch was placed into an Escherichia coli culture medium with irradiation of NIR (pulsed laser by manually on/off). E. coli in direct contact with patch could be killed by local heating on the patch surface. Approximately 99% of the bacteria was killed compared to control test. Therefore, this patch can be applied to wounds to block the entry of bacteria from the outside for the prevention of secondary infections and the acceleration of treatment with the photothermal effect caused by NIR irradiation.
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