Abstract
It is still of great challenge for anaplastic thyroid carcinoma (ATC) treatment since ATC is an extremely destructive and lethal thyroid malignancy. Herein, a kind of multifunctional nanoplatform (denoted as PDA-dsCpG-DOX NP) has been prepared and applied for tri-modal ATC therapy including photothermal therapy (PTT), chemotherapy, and immunotherapy. Polydopamine nanoparticle (PDA NP) serves as a photothermal agent to generate PTT, as well as a carrier of doxorubicin (DOX) and immunotherapeutic DNA (i.e., oligonucleotide comprising unmethylated cytosine-phosphate-guanine dinucleotide (CpG ODN)). The high temperature induced by PTT results in the release of CpG ODNs for immunotherapy and the liberation of DOX for chemotherapy. PDA-dsCpG-DOX NPs exhibit a phenomenal collaborative therapy effect contrasted with a corresponding single therapy or dual-modal treatment. By use of mice bearing C643 thyroid tumors as a model, PDA-dsCpG-DOX NPs have been demonstrated to realize nearly complete tumor growth suppression with good biocompatibility. Hence, PDA-dsCpG-DOX NPs introduce a synergistic scheme for ATC treatment and foreground the congregate effects of tri-modal therapy.
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