Abstract
BackgroundAs one of the leading threats for health among women worldwide, breast cancer has high morbidity and mortality. Surgical resection is the major clinical intervention for primary breast tumor, nevertheless high local recurrence risk and breast tissue defect remain two main clinical dilemmas, seriously affecting survival and quality of life of patients.ExperimentalWe developed a thermoresponsive and injectable hybrid hydrogel platform (IR820/Mgel) by integration of co-loaded porous microspheres (MPs) and IR820 for preventing postoperative recurrence of breast cancer via photothermal therapy and promoting subsequent breast reconstruction.ResultsOur results suggested that IR820/Mgel could quickly heated to more than 50.0 ℃ under NIR irradiation, enabling killing effect on 4T1 cells in vitro and prevention effect on post-surgical tumor recurrence in vivo. In addition, the hydrogel platform was promising for its minimal invasion and capability of filling irregularly shaped defects after surgery, and the encapsulated MPs could help to increase the strength of gel to realize a long-term in situ function in vivo, and promoted the attachment and anchorage property of normal breast cells and adipose stem cells.ConclusionsThis photothermal hydrogel platform provides a practice paradigm for preventing locally recurrence of breast cancer and a potential option for reconstruction of breast defects.Graphic abstract
Highlights
Breast cancer is the most common malignancy in women worldwide [1]
Synthetic hydrogel based on the synthetic polymers have been performed to the postoperative fillers in breast cancer patients, whereas their application for this purpose is limited by their inflammatory and potential toxic by-products of degradation [7, 10]
We have confirmed that polymer microspheres with porous structure and a rough surface could provide more anchor points for attaching of fibroblasts [21,22,23]. It may be a promising option for breast reconstruction through developing the porous microspheres (MPs) loaded nature hydrogel with biocompatibility and low inflammation
Summary
Our results suggested that IR820/Mgel could quickly heated to more than 50.0 °C under NIR irradiation, enabling killing effect on 4T1 cells in vitro and prevention effect on post-surgical tumor recurrence in vivo. The hydrogel platform was promising for its minimal invasion and capability of filling irregularly shaped defects after surgery, and the encapsulated MPs could help to increase the strength of gel to realize a long-term in situ function in vivo, and promoted the attachment and anchorage property of normal breast cells and adipose stem cells
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