Abstract
Bilirubin undergoes photodecomposition by the absorption of energy emitted in the blue region of the visible spectrum. This mechanism can be used as therapy in a disorder that can lead to brain damage if left unchecked. The purpose of this study was to establish a time-dose-response relationship for this treatment modality. Forty-four neonates with elevated bilirubin levels were grouped according to the rate at which energy was delivered (3.5-17 mu W cm-2). The only significant differences between the groups were the total radiant energy received and the 24 h bilirubin response. A nearly linear response was demonstrated between the 24 h bilirubin decrease and the total light energy received.
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