Abstract
Inflammation has gained a pivotal role in the pathophysiology of Acute Coronary Syndrome (ACS). TNF-α is a pro-inflammatory cytokine that could be a potential biomarker in ACS due to its multiple functions. The rs1799964 TNFA polymorphism (−1031 T > C) has been associated with a decrease in gene transcription and cytokine levels.To determine the association of rs1799964 TNFA polymorphism and TNF-α soluble levels in ACS.A total of 251 patients diagnosed with ACS and 164 individuals without cardiovascular diseases classified as the reference group (RG), were included. The rs1799964 polymorphism was genotyped by PCR-RFLP. Soluble protein levels were determined by ELISA. Statistical analyses were performed using chi square and U-Mann Whitney tests.The genotype and allele frequencies were different between ACS and RG (OR = 0.317, p = 0.01; OR = 0.688, p = 0.03 respectively). ACS patients had higher soluble TNF-α levels compared with the RG (31.08 vs 23.00 pg/mL, p < 0.001); according genotype significant differences were observed (T/T: 24.06 vs T/C: 34.95 pg/mL, p = 0.0001) in patients. In the RG, T/T carriers showed discrete lower levels than C/C genotype (22.14 vs 27.83 pg/mL, p = 0.04).The −1031 C allele of the TNFA polymorphism confers protection for the development of ACS. The T/C genotype carriers had higher TNF-α serum levels compared to the T/T genotype in ACS. In addition, the −1031 T > C TNFA polymorphism was associated with dyslipidemia in ACS in a Western Mexican population.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.