Abstract
Photostability of ziprasidone under UVA and UVC irradiation in methanol solution was investigated and structural elucidation of its photodegradation products was performed with the use of reversed phase UHPLC-DAD system coupled with accurate mass high resolution ESI-Q-TOF mass spectrometer. Twelve degradation products were found under UVC irradiation and their masses with high accuracy (0.24–4.35 ppm), formulas, and MS/MS fragmentation spectra were obtained allowing its structural elucidation. Under UVA irradiation only one photodegradation product was found as the effect of the keto-enol tautomerism process of ziprasidone. This photoproduct was also found as one of the three main photodegradation products of ziprasidone under exposition on UVC source. Ziprasidone was shown as a photolabile compound following first-order kinetic reaction with the rate constant k = 6.8348 h−1 (UVC) and k = 0.00383 h−1(UVA).
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