Abstract
One novel nanoplatform with multiple functions including Raman imaging and photodynamic therapy (PDT) capacities was constructed through modifying nanodiamonds (NDs) with photosensitizer chlorin e6 (Ce6). The NDs-Ce6 nanoparticles show enhanced singlet oxygen generation efficiency relative to free Ce6. Cytotoxicity tests indicate that NDs-Ce6 have negligible influence toward HeLa cells vitality under dark condition but enhanced photodynamic ablation upon 660 nm laser irradiation in comparison with free Ce6. In addition, the NDs-Ce6 could be used as Raman imaging probes toward HeLa cells. These results demonstrate that the NDs-Ce6 multifunctional nanoplatform have attractive features using for Raman imaging and PDT. Additionally, a new idea could be provided for designing the multifunctional platform from the work.
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