Photoredox-catalyzed hydroxyfluoroalkylation of alkene with simple fluoroalkyl iodides

Abstract

Hydroxyfluoroalkylation of simple alkenes is presented with readily available fluoroalkyl iodides by the virtue of photoredox catalysis in good efficiency and regioselectivity. This chemistry features mild condition, simple operation and good substrate scope. A variety of styrenes as well as non-activated aliphatic alkenes can be selectively transformed to β-fluoroalkylated alcohols. Preliminary mechanistic studies indicated a radical process with fluoroalkyl radicals which were generated from reductive quenching of photocatalytic circle.