Photoredox-Catalyzed Hydroacylation of Azobenzenes with Carboxylic Acids.

Abstract

Acyl hydrazides are widely found in bioactive compounds and have important applications as versatile synthetic intermediates. In the current report, a photoredox-catalyzed hydroacylation of azobenzenes was disclosed with carboxylic acids as the acylation reagent, affording a variety of N,N'-disubstituted hydrazides. The process possesses the advantages of mild reaction conditions, broad substrate scope, and high efficiency. Preliminary mechanistic investigation indicated that the addition of an acyl radical to the azo compound should be involved.