Abstract
María Paz Villegas‐Pérez, Johnny Di Pierdomenico Spitilli, Ana Martínez Vacas y Diego García Ayuso.Inherited retinal degenerations are genetic diseases that cause irreversible blindness at working age. Although the most common form is retinitis pigmentosa (RP) there are many forms of the disease. More than 100 genetic defects have been documented in RP and therefore genetic treatment for this disease is not possible at present. We have used pharmacological, dietary and cellular therapies to augment photoreceptor survival in two animal models of inherited retinal degeneration with genetic defects also observed in human RP, the P23H1 rat and the RCS rat. Different therapies have shown promising results and may be thus used alone or in combination to promote photoreceptor survival in inherited retinal degenerations.
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