Abstract
Effectiveness and mechanism of argon laser photoradiation therapy was studied in cultured cells. Photosensitizing agents used in this study included acridine orange (AO), Adriacin, Cosmegen and Mithramycin. Among these drugs, AO was most effectively photosensitized to cause cell death, whereas other anti-cancer drugs had little additional effects to their own cytocidal effect by laser irradiation. Photoradiation effect was observed only when cells were irradiated after AO treatment. Irradiation of AO or cells separately did not cause cell death. Therefore interaction between AG and cell was considered indispensable in this modality. Until now AO is the most effective photosensitizer in argon laser photoradiation therapy but some disadvantages such as genotoxicity must be overcome before it is widely applied clinically.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: THE JOURNAL OF JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
