Photoprotective effects of reinforced galactooligosaccharides supplementation against skin damage in hairless mice (LB357)

Abstract

Ultraviolet B (UVB) radiation has been proposed as a main environmental stressor of skin damage because of its mutagenic and immunosuppressive effects as well the generation of reactive oxygen species (ROS). Photoprotective effects of probiotics have a potential to prevent UV‐induced skin damage and have drawn much attention recently. Galactooligosaccharides (GOS) are an important dietary prebiotics and generally defined as non‐digestible food ingredients that promote the function or viability of probiotics via their fermentation, but the effects of reinforced GOS between the immunomodulatory and anti‐inflammatory activities are still unclear. The aim of the present study was to investigate whether the oral administration of high content GOS by using enzyme reaction process to modulate the growth of beneficial bacteria and the immune‐suppressive effect of UVB and skin wrinkle development in male hairless mice. The oral administration of GOS was effective to alleviate skin damage by reducing the expression of primary matrix degrading enzyme as compared to control group, and modulate the water holing capacity and trans‐epidermal water loss. These result supports that a potential protective effect of high content GOS on skin damage induced by UVB exposure, and it may be mediated by the inhibition of ROS and modulation of MMP expression.Grant Funding Source: Supported by Leading Industry Development for Economic Region, MOTIE, Republic of Korea