Year-end Sale % OFF 
Abstract
Ultraviolet (UV) irradiation, particularly ultraviolet A (UVA), stimulates reactive oxygen species (ROS) production in the epidermis and dermis, which plays a major part in the photoageing of human skin. Several studies have demonstrated that cerium oxide nanoparticles (CeO2 NP) can exhibit an antioxidant effect and free radical scavenging activity. However, the protective role of CeO2 NP in skin photoageing and the underlying mechanisms are unclear. In this study, we investigated the effects of CeO2 NP on UVA-irradiated human skin fibroblasts (HSFs) and explored the potential signalling pathway. CeO2 NP had no apparent cytotoxicity, and could reduce the production of proinflammatory cytokines, intracellular ROS, senescence-associated β-galactosidase activity, and downregulate phosphorylation of c-Jun N-terminal kinases (JNKs) after exposure to UVA radiation. Based on our findings, CeO2 NPs have great potential against UVA radiation-induced photoageing in HSFs via regulating the JNK signal-transduction pathway to inhibit oxidative stress and DNA damage.
Highlights
Ultraviolet (UV) irradiation, ultraviolet A (UVA), stimulates reactive oxygen species (ROS) production in the epidermis and dermis, which plays a major part in the photoageing of human skin
We investigated the effects of CeO2 NP on UVA-irradiated human skin fibroblasts (HSFs) and explored the potential signalling pathway
NP were not negatively dyed with phosphotungstic acid, so BSA on the surface of NP could not be observed by transmission electron microscopy (TEM), which may cause the size of CeO2 NP to appear smaller than their actual size
Summary
Ultraviolet (UV) irradiation, ultraviolet A (UVA), stimulates reactive oxygen species (ROS) production in the epidermis and dermis, which plays a major part in the photoageing of human skin. Skin ageing is caused by environmental aggressors and the passage of time, and is one of the most common dermatologic concerns[1,2] It is classified into two types—“intrinsic ageing” (attributed to the influence of genes and hormones) and “extrinsic ageing” (induced by environmental factors such as cigarette smoking, poor nutrition and solar radiation)[3,4]. UVA accounts for >95% of solar UV radiation and is present in sunlight all day It can penetrate deep into the epidermis and dermis to cause photo-carcinogenesis, and has a critical role in photoageing[10]. CeO2 NP can suppress inflammation[28] and diseases related to responses to oxidative stress, such as obesity[29]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
