Abstract
The present work describes the study of the photophysics and dynamics of a prospective anti-cancer antibacterial drug norfloxacin (NFX) within the micro-heterogeneous environment of Aerosol OT (AOT) reverse micelle (RM). The environment sensitive fluorescence spectroscopic behavior of NFX is found to exhibit a significant red-shift with increasing water pool size (w 0 = [water]/[surfactant]) of the RM. A prominent decrease of fluorescence anisotropy of NFX with increasing w 0 demonstrates a relaxation of the motional restrictions imposed on the bound drug molecules with enhanced hydration. These results are further substantiated from our time-resolved measurements. Study of the rotational dynamics of NFX within the RM as a function of w 0 exhibits a typical biexponential decay behavior which has been adequately described on the basis of the wobbling-in-cone model. The rotational dynamical parameters are also calculated for wobbling motion of the drug within the RM as a function of w 0 .
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