Abstract
We have designed and synthesized novel metal-ligand complexes with amine- or acyl- reactive functional groups. These complexes have potential as luminescent probes to investigate bio-macromolecular dynamics on the submicrosecond-to-microsecond timescale. This time scale is of interest, for example, for analysis of the motions associated with large macromolecular assemblies and interactions involving membrane-bound proteins. Here we report the photophysics and structural properties of (1) the complex [HRu(CO)(dicarboxy-bipyridyl)(PPh3)2]+ [PF6]− conjugated to the lipid dipalmitoyl-phosphatidylethanolamine (DPPE) and (2) the complex [(CF3CO2)Ru(CO)-(5aminophen)(Ph2PC2H2PPh2)]+ [PF6]− conjugated to cholesterol. The conjugated complexes were incorporated in unilamellar lipid membrane vesicles to investigate the photophysical properties of these probes in the membrane environment and to evaluate the utility of these probes for investigating the physical properties of lipid membranes.
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