Abstract
Substituted selenodiazoles (piazselenols) were used as ligands to synthesize organometallic ruthenium(II) piano-stool complexes using the precursors ([η6-cymene)RuX2 (where x = Cl, Br and I). Analytical data suggested that two (η6-cymene)Ru motifs were present per ligand in the solid state. However, 1H and 77Se NMR in DMSO solution confirmed the dissociation of the selenodiazole ligand from the ruthenium center. Interestingly, selenodiazole with naphthalene substitutes possess excellent photophysical properties. It showed strong red fluorescence (576 nm) when excited at visible region (488 nm) and was found suitable for use as an imaging agent in HCT 116 cells. Among all ligands examined, only the nitro substituted selenodiazole showed potent anticancer activity against the A2780 cell line.
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Schedule a callMore From: Proceedings of the National Academy of Sciences, India Section A: Physical Sciences
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