Abstract
Abstract— The interaction between products from dimethylnitrosamine photolytic breakdown and DNA is time‐dependent and the reaction with polyguanylic acid is 36 times higher than that occurring with other polyribonucleotides; such interactions occur only if nucleic acids are present during dimethylnitrosamine photolytic breakdown. Among interaction compounds, neither O6‐methyl‐ nor 7‐methylguanine are observable; on the contrary, N‐methylhydrazine and trimethylamine are always found in acid and alkaline hydrolysates of DNA and polynucleotides. These findings are very similar to the results previously found in biological in vivo and in vitro systems and suggest a possible usefulness of this physicochemical system as an analogical model of chemical carcinogenesis.
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