Abstract
AbstractErythrosine- (ERY) induced photosensitized immediate toxic reactions in rabbit skin were studied. Increase in vascular permeability (VP) and accumulation of polymorphonuclear leukocytes (PMNs) were quantitated using radiolabeled human serum albumin ([125I]HSA) and [51Cr] PMNs, respectively. ERY (10–400 nmol) injected intradermally and subsequently exposed to ultraviolet-visible radiation (320–700 nm) (UVA-VIS) for 2 hr produced skin edema in situ due to increase of VP with a dose-response relationship. This increase in VP was approximately 3.5 times when either 100 nmol of ERY or 10 nmol of rose bengal (RB) was injected separately, compared to the respective control sites (protected from UVA-VIS irradiation). The accumulation of PMNs at the sites injected with ERY and exposed to light also showed a dose-response relationship. β-Carotene (100 nmol), when injected intradermally in conjunction with ERY and exposed to light, reduced the leakage of plasma approximately 50% relative to sites without β-c...
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