Abstract
Here we report a facile, efficient, and catalyst-free method to realize C-C cross-coupling of aryl chlorides and inert arenes under UV light irradiation. The aryl radical upon homolytic cleavage of C-Cl bond initiated the nucleophilic substitution reaction with inert arenes to give biaryl products. This mild reaction mode can also be applied to other synthetic reactions, such as the construction of C-N bonds and trifluoromethylated compounds.
Highlights
The biaryl scaffolds are privileged constituents of natural products, pharmaceuticals, agrochemicals, dyes, and polymers [1]
In view of the extensive applications of biaryl intermediates in pharmaceuticals, dyestuff, and perfume, the development of efficient and catalyst-free C-C coupling methods will gain more and more attention because most catalytic methods involve the use of toxic/polluting reagents and the residues must be eliminated from the final products
We provided an efficient and catalyst-free method to realize C-C cross-coupling of aryl chlorides and inert arenes under UV light excitation
Summary
The biaryl scaffolds are privileged constituents of natural products, pharmaceuticals, agrochemicals, dyes, and polymers [1]. Transition-metal-catalyzed direct arylation of aromatic C-H bonds has been extensively developed as a valuable and efficient alternative to traditional cross-couplings in the construction of biaryl compounds [2,3,4,5,6,7] These processes suffered significant problems such as high economic cost and the presence of transition-metal impurities in the final products. We provided an efficient and catalyst-free method to realize C-C cross-coupling of aryl chlorides and inert arenes under UV light excitation This homolytic radical aromatic substitution (HAS) process gave an extremely facile mode to construct biaryl compounds, and its applicability can be extended to form diverse bonds such as trifluoromethylation and C-N cross-coupling reactions
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
