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Abstract
Pulsed laser ablation of blood clots in a fluid-filled blood ves- sel is accompanied by an explosive evaporation process. The resulting vapor bubble rapidly expands and collapses to disrupt the thrombus (blood clot). The hydrodynamic pressures following the bubble expan- sion and collapse can also be used as a driving force to deliver clot- dissolving agents into thrombus for enhancement of laser thrombolysis. Thus, the laser-induced bubble formation plays an important role in the thrombus removal process. We investigate the effects of boundary con- figurations and materials on bubble formation with time-resolved flash photography and high-speed photography. Potential applications in drug delivery using microsecond laser pulses are also discussed. © 1998 So- ciety of Photo-Optical Instrumentation Engineers. (S0091-3286(98)00108-1)
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