Abstract
In this work, an innovative photoelectrochemical (PEC) biosensor based on a new BiVO4/Ag2S heterojunction combined with Exo III-assisted silver nanoclusters (NCs) amplification was reported for DNA (gene P53) detection. BiVO4 is a promising photosensitive material due to its strong visible light absorption, suitable band gap, and safety nontoxicity. However pure BiVO4 suffered from the rapid recombination of photogenerated carriers, which limited its photoelectric conversion efficiency. After Ag+ was generated by target-induced silver NCs amplification reaction, Ag2S was synthesized by ion layer adsorption reaction on the surface of BiVO4 to form the BiVO4/Ag2S heterojunction. Compared with the photocurrent of pure BiVO4, the PEC sensitization of the heterojunction was 112 times. The enhanced photocurrent signal could be used to realize the detection of suppressor gene P53. In addition, the linear detection range of this biosensor was 1 fM-100 nM and the detection limit was 0.42 fM. So this work opened a new avenue for BiVO4/Ag2S heterojunction in biosensing applications and provided a new technology for the early diagnosis of tumors.
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