Abstract
AbstractIn the wide field of laser applications in medicine, the photodynamic therapy is a very fascinating method for cancer diagnosis and therapy. The essential part of this treatment is the photosensitizer used, its selectivity, toxicity and phototoxicity. The first photosensitizer has been haematoporphyrinderivative (HPD); meanwhile a lot of potential dyes have been tested and the run for the “ideal” sensitizer is still going on. Also the reaction mechanisms are probably different, and depend on the dye. The last step in the reaction is the creation of the reactive oxygen molecule, which destroys the tumor cell. The selectivity of this reaction, the higher concentration of the dye in the tumor (cells and the vascular system) compared to the normal tissue, considerably depends on the type of the tumor. Beside this, the parameters of laser irradiation for a successful treatment are very critical. Laser‐tissue interactions limit the applications up to now to special tumor types and tumor stages. Nevertheless, photodynamic therapy will become increasingly important in the future, also in combination with conventional techniques.
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