Abstract
Photodynamictherapy (PDT) using a photo sensitizing agent and several light sources has been shown to have nonspecific and noninvasive effects on superficial cancers. Phthalocyanine (Pc) derivatives as novel photosensitizers, trifluoroethoxy-coatedzinc Pcconjugated with β-cyclodextrin (βCD-4TFEO-Pc) was synthesized and its photodynamic effect in vitro and in vivo was evaluated. βCD-4TFEO-Pc alone was completely non-cytotoxic even at high concentrations, and showed excellentphotodynamic effects in B16-F10 and HT-1080 celllines. The in vivo antitumor effect of βCD-4TFEO-Pc against B16-F10 cells transplanted on to the chorioallantoic membranes of chickembryos was 52.7%, but that of laserirradiation alone and photosensitizer alone was <7% at thedose of 50 μg pereggand 100 J/cm2 (50 mW). These data suggest that βCD-4TFEO-Pc is a useful photosensitizer for the treatment of superficial cancers. If a high-power LED with optimal wavelength is developed, excellent treatment of superficial cancers could be achieved by applying βCD-4TFEO-Pc for PDT.
Highlights
In recent years, photodynamic therapy (PDT) using a photosensitizing agent and several light sources has been shown to have nonspecific effects upon malignant diseases
HT-1080 cells treated with zinc Pc were sensitive to laser irradiation. βCD-4TFEO-Pc alone was completely non-cytotoxic even at a high concentration and showed an excellent photodynamic effect in both cell lines
Talaporfin demonstrated a good photodynamic effect, but high inhibition ratio (IR) were noted in photosensitizers alone and the PDT group at high concentrations
Summary
Photodynamic therapy (PDT) using a photosensitizing agent and several light sources has been shown to have nonspecific effects upon malignant diseases. To ensure that PDT is effective against deep tumors, several investigations are being conducted: development of new photosensitizers, application of light sources with deep penetration into tissues, and control of skin irritation as a diverse effect of PDT with photosensitizers [5]-[7]. Several photosensitizers such as porfimer, talaporfin, temoporfin, and verteporfin have been approved for PDT in many countries [3] [8]-[10]. These photosensitizers are derivatives of porphyrin or chlorin, and need a specific light source using red light at a wavelength of around 650 nm
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