Abstract
One of the main mechanisms of action for photodynamic therapy (PDT) is the destruction of tumor vasculature. We observed the PDT-induced vasculature destruction in a mouse model of skin cancer using two techniques: Photoacoustic microscopy (PAM) and diffuse correlation spectroscopy (DCS). PAM showed high-resolution images of the abnormal microvasculature near the establishing tumor area at pre-PDT, as well as the subsequent destruction of those vessels post-PDT. DCS indicated a significant blood flow decrease after PDT, confirming the vascular destruction. Noninvasive assessment of vascular changes may be indicative of therapy response.
Highlights
Nonmelanoma skin cancers (NMSCs), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are the most common human cancer with more than five million cases treated every year [1]
We have shown recently that blood flow changes assessed with diffuse correlation spectroscopy (DCS), a diffuse optical spectroscopy method to quantify tissue blood flow, can be indicative of photodynamic therapy (PDT) efficacy [17]
We utilized diffuse correlation spectroscopy (DCS) to measure the blood flow changes caused by PDT to investigate potential correlation between microvasculature structure and function
Summary
Nonmelanoma skin cancers (NMSCs), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are the most common human cancer with more than five million cases treated every year [1]. They rarely metastasize, their management has become a real challenge to the health care system due to extensive treatment costs [2]. Cryotherapy, laser and photodynamic therapy (PDT) or a combination thereof may be an attractive alternative treatment option for the management of NMSCs with good to excellent cosmetic outcomes [3]. We utilized diffuse correlation spectroscopy (DCS) to measure the blood flow changes caused by PDT to investigate potential correlation between microvasculature structure and function
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
